Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy.GAD65-/- (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation.One fifth of GAD65 -/- mice experienced stress-induced seizures upon exposure to an open field at 4 weeks of age.In each
Artificial bee colony algorithm for economic load dispatch with wind power energy
This paper presents an efficient Artificial Bee Colony (ABC) algorithm for solving large scale economic load dispatch (ELD) problems in power networks.To realize the ELD, the valve-point loading effect, system load demand, power losses, ramp rate crisp scooter wheels limits and prohibited operation zones are considered here.Simulations were perform
Mathematical analysis of a two-tiered microbial food-web model for the anaerobic digestion process
In this research paper, we presented a four-dimensional mathematical system modeling the anaerobic mineralization of phenol in a two-step microbial food-web.The inflowing concentrations of the hydrogen and the phenol are considered in our model.We considered the case of general class of nonlinear growth kinetics, instead of Monod kinetics.Due to so
Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.
BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.We also found that HI